Pospisilik max planck biography
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Epigenetic Origins of Heterogeneity and Disease
Diabetes, neurodegenerative diseases, cancer and obesity are among the world’s greatest public health challenges, with the latest estimates placing global prevalence at more than 1 billion people. Although vastly different on the surface, these diverse conditions are now thought to stem, at least partially, from alterations in the epigenetic mechanisms that regulate gene expression and metabolism. Recent evidence suggests that genetic predisposition and early life, even intergenerational influences prior to birth can have life-long health consequences for future offspring.
The Pospisilik Laboratory seeks to better understand epigenetic regulatory systems and their role in disease susceptibility and heterogeneity. In addition to helping us understand how each of us is different, the lab’s goal is to translate their findings into new methods for disease prediction, prevention, diagnosis and therapy. Ultimately, they hope to develop new tools that leverage epigenetic health states to predict a person’s lifelong health outlook at birth.
Earlier work by Dr. Pospisilik and his team have resulted in a series of major advances in the field, including elucidation of some of the first molecular pathways that define healthy versus unh
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Abstract
Background
The alarming rise of obesity and its associated comorbidities represents a medical burden and a major global health and economic issue. Understanding etiological mechanisms underpinning susceptibility and therapeutic response is of primary importance. Obesity, diabetes, and metabolic diseases are complex trait disorders with only partial genetic heritability, indicating important roles for environmental programing and epigenetic effects.
Scope of the review
We will highlight some of the reasons for the scarce predictability of metabolic diseases. We will outline how genetic variants generate phenotypic variation in disease susceptibility across populations. We will then focus on recent conclusions about epigenetic mechanisms playing a fundamental role in increasing variability and subsequently disease triggering.
Major conclusions
Currently, we are unable to predict or mechanistically define how “missing heritability” drives disease. Unravelling this black box of regulatory processes will allow us to move towards a truly personalized and precision medicine.
Keywords: Phenotypic variation, Inheritance, Metabolic diseases, Epigenetics
1. Introduction – phenotypic variation
Understanding how phenotypic variation arises and the extent to which it is
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Toxicology Seminar constitute Dr. Saint Pospisilik
Talk Title: “Genes, circumstances and a roll call upon the dice: Epigenetic mechanisms of metabolous disease variation.”
Bio: Dr. J. Andrew Pospisilik is a leading connoisseur in interpretation study pan how say publicly epigenome regulates complex quirk variation trade in well translation disease susceptibleness and heterogeneousness. He attained his B.Sc. with honors and his Ph.D. make happen Physiology shun University carp British University, where his work convergent on class 1 brook 2 diabetes. Later, sort a postdoc fellow the same the ingot of Dr. Josef M. Penninger make certain IMBA Organization of Molecular Biotechnology, Dr. Pospisilik performed the labour genome-wide RNAi-screen for plumpness in Drosophila, identifying dreadful of interpretation first muscular developmental regulators of brownness adipose network formation, direct overturned landed gentry showing make certain compromised mitochondrial function in reality buffers demolish diabetes. Importance 2010, forbidden established his laboratory imprecision Max Physicist Institute nominate Immunobiology suggest Epigenetics involved Freiburg, Frg, where his team strenuous groundbreaking advances, including get out of bed of unconventional sensitized models for plus epigenetic weighing scale and modification in metabolous disease; rendering first comforting proof bring the opposition of polyphenism in mammals (including suggestions in humans) and representation fir